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WNT PROTEINS
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DeCS
Descriptor
English
:
Wnt Proteins
Descriptor
Spanish
:
Proteínas Wnt
Descriptor
Portuguese
:
Proteínas Wnt
Tree Number:
D12.644.276.984
D12.776.467.984
D23.529.984
Definition
English
:
Wnt proteins
are a large
family
of secreted
glycoproteins
that play essential roles in
EMBRYONIC AND FETAL DEVELOPMENT
, and tissue
maintenance
. They bind to
FRIZZLED RECEPTORS
and act as PARACRINE PROTEIN FACTORS to initiate a variety of
SIGNAL TRANSDUCTION
PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator
BETA CATENIN.
History Note
English
:
2006(1987)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50759
Unique Identifier:
D051153
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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